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Oral intake of cissus quadrangularis (petroleum ether extract of the stem; % yield) in a rat model mimicking menopause (ovarectomized rats) at a dose of 500mg/kg for ninety days is able to fully prevent losses of bone strength and prevent up to 86% of the losses in bone thickness;  cissus quadrangularis showed comparable efficacy to /kg of the SERM known as raloxifene, and while this study is duplciated in Medline  the design has been replicated where a month of cissus quadrangularis supplementation (500mg/kg petroleum ether extract) was comparable in efficacy 25mg/kg raloxifene in ovarectomized rats.