Colostrum Replacers & Supplements - Do not confuse these two types of products. Newborns must have colostrum during the first hours after birth. If the dam is colostrum deficient, you must use a colostrum replacer. The best colostrum replacer is colostrum saved (and frozen) from does on your property who have already kidded. This colostrum will have antibodies that provide the kids needed immunity to the organisms existing in your particular location. If you don't have a supply of frozen colostrum, then you must use a commercially-prepared goat colostrum replacer (*not* "supplement"). Do not use colostrum or colostrum replacer beyond the first 48 hours of the kid's life. Switch to goat milk or goat milk replacer. Colostrum has already done its job for the newborn after 48 hours and the kid's body can better digest goat milk. I use Ultra-Bac 24 all-species milk replacer (Milk Products).
The absolute bioavailability of oral ciprofloxacin is within a range of 70–80% with no substantial loss by first pass metabolism. An intravenous infusion of 400-mg ciprofloxacin given over 60 minutes every 12 hours has been shown to produce an area under the serum concentration time curve (AUC) equivalent to that produced by a 500-mg oral dose given every 12 hours. An intravenous infusion of 400 mg ciprofloxacin given over 60 minutes every 8 hours has been shown to produce an AUC at steady-state equivalent to that produced by a 750-mg oral dose given every 12 hours. A 400-mg intravenous dose results in a C max similar to that observed with a 750-mg oral dose. An infusion of 200 mg CIPRO given every 12 hours produces an AUC equivalent to that produced by a 250-mg oral dose given every 12 hours (Table 10).