N-Acetyl L-Cysteine (150mg): N-Acetyl L-Cysteine (NAC) is well known for its antioxidant and liver protecting abilities.[25,26,27] NAC is the primary substrate for glutathione, a non-essential amino acid that’s responsible for scavenging free radical from around the body. This essentially makes glutathione an incredibly powerful antioxidant.[28,29] If your body is deficient in NAC, it don’t have the required “building blocks” to synthesize glutathione, which can lead to an accumulation of reactive oxygen species (ROS) and oxidative stress. In case you weren’t aware oxidative stress is often a side effect of prohormone use! Supplementing with AC increases glutathione which effectively helps decrease ROS formation and supports optimal liver function.
TIR1 proteins are F-box proteins that have three different domains giving them the ability to bind to three different ligands: an SCF TIR1 ubiquitin ligase complex (using the F-box domain), auxin  (so TIR1 proteins are auxin receptors), and Aux/IAA proteins (via a degron domain). Upon binding of auxin, a TIR1 protein's degron domain has increased affinity for Aux/IAA repressor proteins, which when bound to TIR1 and its SCF complex undergo ubiquitination and subsequent degradation by a proteasome . The degradation of Aux/IAA proteins frees ARF proteins to activate or repress genes at whose promoters they are bound.