Beta ecdysteroids

In male rats, Ecdy treatment increased muscle fiber size, serum IGF-1 increased, and corticosteron and 17?-estradiol (E2) decreased. In differentiated C2C12 myoblastoma cells, treatment with Ecdy, dihydrotestosterone, IGF-1 but also E2 results in hypertrophy. Hypertrophy induced by E2 and Ecdy could be antagonized with an antiestrogen but not by an antiandrogen. In HEK293 cells transfected with ER alpha (ER?) or ER?, Ecdy treatment transactivated a reporter gene. To elucidate the role of ER? in Ecdy-mediated muscle hypertrophy, C2C12 myotubes were treated with ER? (ALPHA) and ER? (BETA) selective ligands. Ecdy and BETA treatment but not ALPHA induced hypertrophy. The effect of Ecdy, E2, and BETA could be antagonized by an ER?-selective antagonist (ANTIBETA). In summary, our results indicate that ER? is involved in the mediation of the anabolic activity of the Ecdy.

20-Hydroxyecdysterone (referred to here as ecdysterone) is a member of a family of insect and plant derived steroid hormone, known as ecdysteroids. There are more than 300 known ecdysteroids, but 20-hydroxyecdysterone has been the most extensively researched ecdysteroid that has anabolic properties without the androgenic side effects. Ecdysterone is known to increase wound healing and protein synthesis. Many people have tried ecdysterone orally with little or no results even at very high doses. The reason for this is the same as base testosterone, poor oral absorption, and a very short (11 minute) duration of action. It is proven that ecdysterone is rapidly cleared by the body, which is why it is perfect for transdermal delivery. By using this compound in a transdermal matrix, both of these obstacles are overcome, allowing you to get the maximum anabolic benefit from this compound. The first use of ecdysterone was by Russian Olympians who were vague on how they administered the compound It was wrongly assumed that ecdysterone was take orally, but new research suggests that the Russians injected a synthetic analog of ecdysterone to increase performance. Now, there is no way you would want to inject the 95% pure plant extracts that are currently available, but they are perfect for transdermal delivery, which gives you the benefits that the Russians derived without the danger of injections.

Steroid isolation , depending on context, is the isolation of chemical matter required for chemical structure elucidation, derivitzation or degradation chemistry, biological testing, and other research needs (generally milligrams to grams, but often more [38] or the isolation of "analytical quantities" of the substance of interest (where the focus is on identifying and quantifying the substance (for example, in biological tissue or fluid). The amount isolated depends on the analytical method, but is generally less than one microgram. [39] [ page needed ] The methods of isolation to achieve the two scales of product are distinct, but include extraction , precipitation, adsorption , chromatography , and crystallization . In both cases, the isolated substance is purified to chemical homogeneity; combined separation and analytical methods, such as LC-MS , are chosen to be "orthogonal"—achieving their separations based on distinct modes of interaction between substance and isolating matrix—to detect a single species in the pure sample. Structure determination refers to the methods to determine the chemical structure of an isolated pure steroid, using an evolving array of chemical and physical methods which have included NMR and small-molecule crystallography . [2] :10–19 Methods of analysis overlap both of the above areas, emphasizing analytical methods to determining if a steroid is present in a mixture and determining its quantity. [39]

[1] Phytoecdysteroids: Understanding Their Anabolic Activity  by Jonathan Gorelick-Feldman at Rutgers
[2]  Ecdysteroids from Chenopodium quinoa Willd., an ancient Andean crop of high nutritional value
[3] Level and distribution of 20-hydroxydysone during Pfaffi glomerata development
[4] Phytoecdysteroids: Understanding Their Anabolic Activity by Jonathan Gorelick-Feldman at Rutgers
[5] Effects and applications of arthropod steroid hormones (ecdysteroids) in mammals.
[6] Practical uses for ecdysteroids in mammals including humans: an update

Beta ecdysteroids

beta ecdysteroids

[1] Phytoecdysteroids: Understanding Their Anabolic Activity  by Jonathan Gorelick-Feldman at Rutgers
[2]  Ecdysteroids from Chenopodium quinoa Willd., an ancient Andean crop of high nutritional value
[3] Level and distribution of 20-hydroxydysone during Pfaffi glomerata development
[4] Phytoecdysteroids: Understanding Their Anabolic Activity by Jonathan Gorelick-Feldman at Rutgers
[5] Effects and applications of arthropod steroid hormones (ecdysteroids) in mammals.
[6] Practical uses for ecdysteroids in mammals including humans: an update

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